منابع مشابه
Structural studies on cross-linked regions of elastin.
A novel use of Edman degradation was made in the study of desmosineand isodesmosine-containing elastolytic peptides of bovine ligamentum nuchae elastin. The elastolysis of elastin produced peptides with the cleavage at or near the NH,-terminals of desmosine and isodesmosine cross-links. Therefore, it became possible to release single chain peptides from the carboxyl groups of these cross-links ...
متن کاملIsolation and characterization of cross-linked peptides from elastin.
Two peptides containing the desmosine cross-link were isolated and purified from a subtilisin digest of oxalic acidsolubilized elastin. Molecular weights averaged approximately 6000. Automated sequence data suggest that the desmosines cross-link two polypeptide chains and that both desmosine and isodesmosine are present in the same primary sequence approximately equally substituted. The primary...
متن کاملCross-linked elastin and collagen degradation products in the urine of patients with scleroderma.
OBJECTIVE To measure the urinary excretion of specific cross-link amino acid markers for mature elastin (desmosine [DES] and isodesmosine [IDES]) and fibrillar collagen (hydroxylysylpyridinoline [HP] and lysylpyridinoline [LP]) in systemic sclerosis (SSc) patients and healthy controls. METHODS Urine specimens from 20 patients with SSc and 22 controls were assessed for DES, IDES, HP, and LP us...
متن کاملCross-linked open-pore elastic hydrogels based on tropoelastin, elastin and high pressure CO2.
In this study the effect of high pressure CO(2) on the synthesis and characteristics of elastin-based hybrid hydrogels was investigated. Tropoelastin/alpha-elastin hybrid hydrogels were fabricated by chemically cross-linking tropoelastin/alpha-elastin solutions with glutaraldehyde at high pressure CO(2). Dense gas CO(2) had a significant impact on the characteristics of the fabricated hydrogels...
متن کاملDeformation responses of a physically cross-linked high molecular weight elastin-like protein polymer.
Recombinant protein polymers were synthesized and examined under various loading conditions to assess the mechanical stability and deformation responses of physically cross-linked, hydrated, protein polymer networks designed as triblock copolymers with central elastomeric and flanking plastic-like blocks. Uniaxial stress-strain properties, creep and stress relaxation behavior, as well as the ef...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.004322